The visual discrimination of different structures in one or multiple combined volume data sets is generally done with individual transfer functions that can usually be adapted interactively. Immersive virtual environments support the depth perception and thus the spatial orientation in these volume visualizations. However, complex 2D menus for elaborate transfer function design cannot be easily integrated. We therefore present an approach for changing the color mapping during volume exploration with direct volume interaction and an additional 3D widget. In this way we incorporate the modification of a color mapping for a large number of discretely labeled brain areas in an intuitive way into the virtual environment. We use our approach for the analysis of a patient’s data with a brain tissue degenerating disease to allow for an interactive analysis of affected regions.